Electrophysiology
Stable, drift-free micromanipulation for patch-clamp and intracellular recording, at the bench, in vivo, and in plant cells.
A patch-clamp or sharp-electrode recording lives or dies on stability: the pipette has to reach the cell with micrometre precision and then stay put, drift-free and vibration-free, for minutes to hours. Conventional manipulators struggle to hold that line.
Kleindiek’s Nanomotor® manipulators were built for it: high resonance frequency, drift around 1 nm/min, sub-nanometre steps, and compact enough to sit right by the preparation. The same family scales from the benchtop MM3A-LS to a single-axis motor light enough to ride on an animal’s head. The articles below work through patch-clamp positioning, recording in freely moving animals, and impaling walled plant cells.
Articles & videos
Short, focused reads and in-microscope footage — start with the introduction or jump to a technique.
Technical deep-dives
Patch-clamp positioning
Holding a patch pipette drift-free for the length of a recording.
Patch clamp in freely moving animals
A head-mountable Nanomotor® that advances and anchors the pipette on a moving animal.
Impaling plant cells
Microelectrode impalement of walled cells such as stomatal guard cells.
Products used
MM3A-LS
The MM3A micromanipulator configured for highly sensitive electrophysiology — long-term stability and sub-nanometre precision.
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in vivo Nanomotor
A single-axis Nanomotor® light and rigid enough to ride on an animal's head — for patch-clamp recording in freely moving animals.
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